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New Hope for Patients With Dupuytren's Contracture

September 28, 2020 5 Comments

The Biology of Dupuytren's Contracture

 

For a long time, the biology of Dupuytren’s contracture has remained a mystery. This has made the race for a cure much harder than people had previously anticipated. 


The cellular components involved in the pathogenesis of Dupuytren’s contracture include changes in growth factors, disturbed protein expression of the cytokine cells, alterations in genes as well as a change in the components of the extracellular.


On the other hand, the histology of Dupuytren’s contracture shows a varying increase in the levels of collagen type I and II, myoglobin protein in the tissues of the palm. 


These varying levels trigger the appearance of nodules in the palm. These nodules then slowly progress into a more prominent cord that ‘pulls’ the fingers inwards.


The information available on the biology of Dupuytren’s contracture is valuable, yet the overall etiology of the disease remains unknown. 


The risk factors of the disease are just as vague. This makes it impossible for scientists and researchers to look for a definite cure that can eliminate the disease forever. 

New Studies and Research

Thanks to constant research and analysis, scientists have now been able to pinpoint the exact cells that are responsible for the progression or aggravation of Dupuytren’s contracture.


Recent studies found that a specific drug that goes by the name of  ‘adalimumab’ may actually help in the elimination of the cells that cause Dupuytren’s contracture to progress. 


Scientists were able to find that out after realizing Tumor Necrosis Factor (NTF) is actually what causes the abnormal development of myofibroblast cells. These cells are responsible for the formation of nodules in the palmar fascia of those affected by Dupuytren’s contracture. 


The drug acts as an anti-TNF agent and works on presenting the formation of such nodules. 


A professor at the University of Oxford has proposed the initiation of clinical trials to see whether or not the drug is a promising cure for those suffering from the hand-mobilizing disease. 

How it Would Work

Here’s the proposal:


The anti-TNF drug or Adalimumab would be injected into the developing nodules present in the palmar fascia of those affected by Dupuytren’s contracture. 


The main job of this drug would be to inhibit or pause the growth of nodules, thus preventing the disease from progressing even further. However, we aren’t yet sure how effective or safe this option is.


It is still not available as a for-sure treatment of Dupuytren’s contracture. Until then, you can use creams as they’re safe and reliable.

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5 Responses

Conrad Simon
Conrad Simon

September 29, 2020

What is the name of the cream referred to in this article that is supposed to be helpful and where can I get it??

Marie Batchelder
Marie Batchelder

September 29, 2020

I have a start of this deasease in both hands and I m really concern…

Mary Bernhardt
Mary Bernhardt

September 29, 2020

Where are the clinical trials being held and is it possible to be a participant?

psansone
psansone

September 29, 2020

My dupuytren’s I believe started approximate two years before any physical signs or deformations. I developed a tenderness to pressure in the palm.
The current expression began with a nodule in my palm on the ring finger tendon (I had been treated for trigger finger in the past. In rapid succession, nodules developed across my palm at the tendon junction. Given the rate of development (compared to comments from others), I was quite concerned and due to covid, surgical procedures (elective) were not offered.
Glad to have been delayed! I started with the cream. Not much to show initially, but now (about 4 months in) I believe I have some size reduction of the nodules in the palm and it has not been “spreading”.
Also applying to the tendon sheath and pumps associated with the trigger finger, but no marked progress in that situation.

Tina Dahmer
Tina Dahmer

September 29, 2020

I really need help soon. My pinky finger is already turned under and pulling on my other fingers. The other hand has many nodules already and growing quite fast. Please help.

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